Interaction of NMDA Receptor and Pacemaking Mechanisms in the Midbrain Dopaminergic Neuron
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چکیده
منابع مشابه
Interaction of NMDA Receptor and Pacemaking Mechanisms in the Midbrain Dopaminergic Neuron
Dopamine neurotransmission has been found to play a role in addictive behavior and is altered in psychiatric disorders. Dopaminergic (DA) neurons display two functionally distinct modes of electrophysiological activity: low- and high-frequency firing. A puzzling feature of the DA neuron is the following combination of its responses: N-methyl-D-aspartate receptor (NMDAR) activation evokes high-f...
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Neuroscientists study the function of the brain by investigating how neurons in the brain communicate. Many investigators look at changes in the electrical activity of one or more neurons in response to an experimentally-controlled input. The electrical activity of neurons can be recorded in isolated brain slices using patch clamp techniques with glass micropipettes. Traditionally, experimenter...
متن کاملDopaminergic neurons modulate GABA neuron migration in the embryonic midbrain
INTRODUCTION Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually dwell in regions distinct from their origin. From ventricular zones, neurons and/or neuronal progenitors navigate along diverse courses, radially and tangentially, to their final destination and integrate into specific brain circuits (Corbin et al., 2001; Hatten, ...
متن کاملDopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.
Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficien...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0069984